The Role of Transcription Factor FOXK2 in Hepatocellular Carcinoma: A Retrospective Analysis

Houhong Wang

Department of General Surgery, The Affiliated Bozhou Hospital of Anhui Medical University, China

*Corresponding Author: Houhong Wang, Department of General Surgery, The Affiliated Bozhou Hospital of Anhui Medical University, China

DOI: 10.64258/3067-7130.2025.1020021

Submission Date: March 14, 2025

Published Date: June 26, 2025

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Abstract

This retrospective study comprehensively analyzed the role of transcription factor FOXK2 in hepatocellular carcinoma (HCC). Data from PubMed - related research articles were collected, covering FOXK2\'s regulatory mechanisms, associations with HCC clinical features, and biomarker potential. FOXK2 is abnormally activated in HCC, and the PIAS4 - FOXK2 axis is crucial for HCC development and chemotherapy resistance. FOXK2 directly regulates multiple genes involved in de novo nucleotide synthesis, and its high expression correlates with poor HCC patient prognosis. Our findings suggest FOXK2 could be a novel HCC diagnostic and prognostic biomarker, and targeting FOXK2 - related pathways may offer new HCC treatment strategies.

Keywords

Hepatocellular carcinoma, FOXK2, Transcription factor, Biomarker, Nucleotide synthesis

Citation

Houhong Wang (2025) The Role of Transcription Factor FOXK2 in Hepatocellular Carcinoma: A Retrospective Analysis. On J Clin & Med Case Rep 1(5): 1-5.