Immunotherapy in Colorectal Cancer: A Review

lfredo Colombo* and Concetta Maria Porretto*

Oncology Unit, C.D.C Macchiarella, Italy

*Corresponding Author: Alfredo Colombo, Oncology Unit, C.D.C Macchiarella, Viale Regina Margherita, 25 Palermo, 90138, Italy.

DOI: 10.64258/3067-7130.2025.1020013

Submission Date: April 20, 2025

Published Date: April 28, 2025

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Abstract

In the world, colorectal cancer is the second most deadly and third most frequent type of cancer. Dietary and behavioural style are the primary predisposing cause. Traditional therapies like surgery, radiation, and chemotherapy are the mainstay of treatment for this disease. More efficient therapies with fewer adverse effects are desperately needed because of its high prevalence and high morbidity. Immunotherapy is one of the fastestgrowing treatments and has emerged as a possible therapeutic alternative in recent years. By boosting the immune system\'s ability to identify and combat cancer cells, immunotherapy prevents the growth of tumors. The most recent immunotherapies for oncolytic viruses, tumor-infiltrating lymphocytes, cell therapy, and immune checkpoint inhibitors are discussed in this study. Some of these are utilized in therapeutic treatment and have demonstrated encouraging outcomes in clinical trials.

Keywords

Colorectal Cancer, Immunotherapy, Immune Checkpoint Inhibitors, Adoptive Cell Therapy, Oncolytic Virus

Citation

Alfredo C, Concetta MP (2025) Immunotherapy in Colorectal Cancer: A Review. On J Clin & Med Case Rep 1(3): 1-17.